Target
RNA-directed RNA polymerase
Ligand
BDBM50183506
Substrate
n/a
Meas. Tech.
ChEMBL_337076 (CHEMBL864354)
IC50
69300±n/a nM
Citation
 Koch, UAttenni, BMalancona, SColarusso, SConte, IDi Filippo, MHarper, SPacini, BGiomini, CThomas, SIncitti, ITomei, LDe Francesco, RAltamura, SMatassa, VGNarjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 49:1693-705 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50183506
Synonyms:
1-allyl-5-hydroxy-2-(3-nitro-2-thienyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid | CHEMBL206511
Type:
Small organic molecule
Emp. Form.:
C12H9N3O6S
Mol. Mass.:
323.281
SMILES:
OC(=O)c1nc(-c2sccc2[N+]([O-])=O)n(CC=C)c(=O)c1O
Structure:
Search PDB for entries with ligand similarity: