Target
RNA-directed RNA polymerase
Ligand
BDBM50158845
Substrate
n/a
Meas. Tech.
ChEMBL_337080 (CHEMBL864365)
IC50
45±n/a nM
Citation
 Koch, UAttenni, BMalancona, SColarusso, SConte, IDi Filippo, MHarper, SPacini, BGiomini, CThomas, SIncitti, ITomei, LDe Francesco, RAltamura, SMatassa, VGNarjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 49:1693-705 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50158845
Synonyms:
2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-dihydroxypyrimidine-4-carboxylic acid | 2-[3-({[(2-chlorobenzyl)amino]carbonyl}amino)-2-thienyl]-5,6-dihydroxypyrimidine-4-carboxylic acid | 2-{3-[3-(2-Chloro-benzyl)-ureido]-thiophen-2-yl}-5-hydroxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid | CHEMBL175882
Type:
Small organic molecule
Emp. Form.:
C17H13ClN4O5S
Mol. Mass.:
420.827
SMILES:
OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)NCc1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: