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Target
Matrilysin
Ligand
BDBM50183711
Substrate
n/a
Meas. Tech.
ChEMBL_354470 (CHEMBL853105)
Ki
18±n/a nM
Citation
 Gilmore, JL; King, BW; Harris, C; Maduskuie, T; Mercer, SE; Liu, RQ; Covington, MB; Qian, M; Ribadeneria, MD; Vaddi, K; Trzaskos, JM; Newton, RC; Decicco, CP; Duan, JJ Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett 16:2699-704 (2006) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50183711
Synonyms:
CHEMBL208009 | N-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide
Type:
Small organic molecule
Emp. Form.:
C25H28N4O4
Mol. Mass.:
448.5142
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCNCC2)c2ccccc2n1
Structure:
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