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Target
cGMP-dependent protein kinase
Ligand
BDBM50183921
Substrate
n/a
Meas. Tech.
ChEMBL_350591 (CHEMBL868999)
IC50
3.7±n/a nM
Citation
 Qian, X; Liang, GB; Feng, D; Fisher, M; Crumley, T; Rattray, S; Dulski, PM; Gurnett, A; Leavitt, PS; Liberator, PA; Misura, AS; Samaras, S; Tamas, T; Schmatz, DM; Wyvratt, M; Biftu, T Synthesis and SAR studies of diarylpyrrole anticoccidial agents. Bioorg Med Chem Lett 16:2817-21 (2006) [PubMed]  Article 
Target
Name:
cGMP-dependent protein kinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
112911.27
Organism:
Eimeria tenella
Description:
ChEMBL_469577
Residue:
1003
Sequence:
MGACSSKAQHQTRDPEPREQQAAQEQKSTGPSGAPNDAPAPAEAERKMSGSSATAPKGEMPTASTGTPEQQQQQQQQQQQQQEQQQHPEHQQSEKQQQHGEEQQQERKPSQQQQNEEAAAPHKHGGERKVQKAIKQQEDTQAEDARLLGHLEKREKTPSDLSLIRDSLSTNLVCSSLNDAEVEALANAVEFFTFKKGDVVTKQGESGSYFFIVHSGEFEVIVNDKVVNKILTGQAFGEISLIHNSARTATIKTLSEDAALWGVQRQVFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVQSFQPGQAIVKEGEKGDVLYILKSGKALVSIKNKEVRVLQRGEYFGERALLYDEPRSATITAEEPTVCVSIGRDLLDRVLGNLQHVLFRNIMLEALQQSKVFASFPTEQLSRLIGSVVVKDYPENYIILDRENRTRASASALFSAQGVRFFFVLEGEVSVFAYKDKSSSSSSSSSSSSSSSSAEGEMELHLIDTLKRGQAFGDEYVLSPNKPFAHCVKSNGPTKLALLTASALTATLGGQDIDETLDYNNKLAITKKMYIFRYLSEQQTQTLIKAFKTVRYTQGESIIREGEIGSRFFIIKLGEVVILKGEKRVRTLGRHDYFGERALLHDERRSATVAANSPEVDLWVVDKDVFLQIVKGPMLTHLEERIRMQDTKVEFKDLNVVRVVGRGTFGTVKLVQHIPTQMRYALKCVSRKSVVALNQQDHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLGRYQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYTLVGTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFRDILAGKLIFPHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFSDFDWDRLAGRDLSPPLLPKGEIYAEDAEEGGLDIEEDEGIELEDEYEWDKDF
  
Inhibitor
Name:
BDBM50183921
Synonyms:
4-(2-(4-fluorophenyl)-5-(piperidin-1-ylmethyl)-1H-pyrrol-3-yl)pyridine | CHEMBL381929
Type:
Small organic molecule
Emp. Form.:
C21H22FN3
Mol. Mass.:
335.4179
SMILES:
Fc1ccc(cc1)-c1[nH]c(CN2CCCCC2)cc1-c1ccncc1
Structure:
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