Target
Prostaglandin D2 receptor
Ligand
BDBM50184232
Substrate
n/a
Meas. Tech.
ChEMBL_364757 (CHEMBL871219)
Ki
4.4±n/a nM
Citation
 Sturino, CFLachance, NBoyd, MBerthelette, CLabelle, MLi, LRoy, BScheigetz, JTsou, NBrideau, CCauchon, ECarriere, MCDenis, DGreig, GKargman, SLamontagne, SMathieu, MCSawyer, NSlipetz, DO'Neill, GWang, ZZamboni, RMetters, KMYoung, RN Identification of an indole series of prostaglandin D2 receptor antagonists. Bioorg Med Chem Lett 16:3043-8 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor
Synonyms:
PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:
Enzyme
Mol. Mass.:
40288.87
Organism:
Homo sapiens (Human)
Description:
Q13258
Residue:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
  
Inhibitor
Name:
BDBM50184232
Synonyms:
2-(5-bromo-4-((2,3-dichlorothieno[3,2-b]pyridin-5-yl)methyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid | CHEMBL210744
Type:
Small organic molecule
Emp. Form.:
C22H17BrCl2N2O4S2
Mol. Mass.:
588.321
SMILES:
CS(=O)(=O)c1cc(Br)c2n(Cc3ccc4sc(Cl)c(Cl)c4n3)c3C(CC(O)=O)CCc3c2c1
Structure:
Search PDB for entries with ligand similarity: