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Target
Dimer of Tryptase beta-2
Ligand
BDBM50184499
Substrate
n/a
Meas. Tech.
ChEMBL_365130 (CHEMBL867493)
IC50
5±n/a nM
Citation
 Miyazaki, Y; Kato, Y; Manabe, T; Shimada, H; Mizuno, M; Egusa, T; Ohkouchi, M; Shiromizu, I; Matsusue, T; Yamamoto, I Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. Bioorg Med Chem Lett 16:2986-90 (2006) [PubMed]  Article 
Target
Name:
Dimer of Tryptase beta-2
Synonyms:
Tryptase beta-1/beta-2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 365130
Components:
This complex has 2 components.
Component 1
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Component 2
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50184499
Synonyms:
CHEMBL208638 | N-(2-(3-(4-(aminomethyl)phenyl)propylamino)ethyl)-1-chloronaphthalene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C22H26ClN3O2S
Mol. Mass.:
431.979
SMILES:
NCc1ccc(CCCNCCNS(=O)(=O)c2ccc3ccccc3c2Cl)cc1
Structure:
Search PDB for entries with ligand similarity: