Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Ligand
BDBM50185359
Substrate
n/a
Meas. Tech.
ChEMBL_344886 (CHEMBL870710)
IC50
160±n/a nM
Citation
 Devreux, VWiesner, JGoeman, JLVan der Eycken, JJomaa, HVan Calenbergh, S Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. J Med Chem 49:2656-60 (2006) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms:
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXP) | 1-Deoxyxylulose 5-phosphate reductoisomerase (DXR) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase | DXR_ECOLI | dxr | ispC | yaeM
Type:
Protein
Mol. Mass.:
43384.52
Organism:
Escherichia coli
Description:
P45568
Residue:
398
Sequence:
MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
  
Inhibitor
Name:
BDBM50185359
Synonyms:
2-[N-(acetyl),N-(hydroxy)aminomethyl]-cyclopropylphosphonic Acid | CHEMBL380319
Type:
Small organic molecule
Emp. Form.:
C6H12NO5P
Mol. Mass.:
209.1369
SMILES:
CC(=O)N(O)CC1CC1P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: