Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50185377
Substrate
n/a
Meas. Tech.
ChEMBL_360161 (CHEMBL871260)
Ki
11±n/a nM
Citation
 Peschke, B; Bak, S; Hohlweg, R; Nielsen, R; Viuff, D; Rimvall, K Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides are potent antagonists of the human H3-receptor. Bioorg Med Chem Lett 16:3162-5 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50185377
Synonyms:
(S)-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)(5-(trifluoromethoxy)benzofuran-2-yl)methanone | CHEMBL381088
Type:
Small organic molecule
Emp. Form.:
C19H21F3N2O3
Mol. Mass.:
382.3768
SMILES:
FC(F)(F)Oc1ccc2oc(cc2c1)C(=O)N1CCC[C@H]1CN1CCCC1
Structure:
Search PDB for entries with ligand similarity: