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Target
Glutathione reductase, mitochondrial
Ligand
BDBM50185398
Substrate
n/a
Meas. Tech.
ChEMBL_360715 (CHEMBL869332)
IC50
>100000±n/a nM
Citation
 Bi, X; Lopez, C; Bacchi, CJ; Rattendi, D; Woster, PM Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity. Bioorg Med Chem Lett 16:3229-32 (2006) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50185398
Synonyms:
CHEMBL382434 | N-(3,3-diphenyl-propyl)-N'-[3-(3-{3-[N'-(3,3-diphenyl-propyl)-guanidino]-propylamino}-propylamino)-propyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C41H56N8
Mol. Mass.:
660.9369
SMILES:
NC(NCCC(c1ccccc1)c1ccccc1)=NCCCNCCCNCCCN=C(N)NCCC(c1ccccc1)c1ccccc1 |w:18.20,30.31|
Structure:
Search PDB for entries with ligand similarity: