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TargetInosine Monophosphate Dehydrogenase Type 1 (IMPDH1)
LigandBDBM50185592
Substrate/Competitorn/a
Meas. Tech.ChEMBL_371820
IC50 38±n/a nM
Citation Watkins, WJChen, JMCho, AChong, LCollins, NFardis, MHuang, WHung, MKirschberg, TLee, WALiu, XThomas, WXu, JZeynalzadegan, AZhang, J Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Bioorg Med Chem Lett16:3479-83 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1)
Name:Inosine-5'-monophosphate dehydrogenase (IMPDH)
Synonyms:IMP dehydrogenase 1 | IMPD 1 | IMPDH-I | Inosine-5''-monophosphate dehydrogenase 1
Type:Enzyme
Mol. Mass.:55407.70
Organism:Homo sapiens (Human)
Description:Recombinant IMPDH1 expressed in E. coli.
Residue:514
Sequence:
MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50185592
NameBDBM50185592
Synonyms:(E)-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2-methylbut-2-enyloxy)methylphosphonic acid | CHEMBL209069
TypeSmall organic molecule
Emp. Form.C17H23O7P
Mol. Mass.370.3341
SMILESCCc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)COCP(O)(O)=O
Structure
n/a