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Target
Estrogen receptor beta
Ligand
BDBM50185852
Substrate
n/a
Meas. Tech.
ChEMBL_371968 (CHEMBL852961)
IC50
32±n/a nM
Citation
 Wilkening, RR; Ratcliffe, RW; Tynebor, EC; Wildonger, KJ; Fried, AK; Hammond, ML; Mosley, RT; Fitzgerald, PM; Sharma, N; McKeever, BM; Nilsson, S; Carlquist, M; Thorsell, A; Locco, L; Katz, R; Frisch, K; Birzin, ET; Wilkinson, HA; Mitra, S; Cai, S; Hayes, EC; Schaeffer, JM; Rohrer, SP The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands. Bioorg Med Chem Lett 16:3489-94 (2006) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50185852
Synonyms:
7-hydroxy-3-oxo-9a-phenyl-2,3,9,9a-tetrahydro-1H-fluorene-4-carbonitrile | CHEMBL211739
Type:
Small organic molecule
Emp. Form.:
C20H15NO2
Mol. Mass.:
301.3386
SMILES:
Oc1ccc2C3=C(C#N)C(=O)CCC3(Cc2c1)c1ccccc1 |c:5|
Structure:
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