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TargetEstradiol receptor beta (ERβ)
LigandBDBM50185870
Substrate/Competitorn/a
Meas. Tech.ChEMBL_371968
IC50 28±n/a nM
Citation Wilkening, RRRatcliffe, RWTynebor, ECWildonger, KJFried, AKHammond, MLMosley, RTFitzgerald, PMSharma, NMcKeever, BMNilsson, SCarlquist, MThorsell, ALocco, LKatz, RFrisch, KBirzin, ETWilkinson, HAMitra, SCai, SHayes, ECSchaeffer, JMRohrer, SP The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands. Bioorg Med Chem Lett16:3489-94 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Estradiol receptor beta (ERβ)
Name:Estrogen receptor
Synonyms:ER-beta | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:Protein
Mol. Mass.:59238.43
Organism:Homo sapiens (Human)
Description:Q92731
Residue:530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50185870
NameBDBM50185870
Synonyms:9a-ethyl-7-hydroxy-4-methyl-1,2,9,9a-tetrahydrofluoren-3-one | CHEMBL212675
TypeSmall organic molecule
Emp. Form.C16H18O2
Mol. Mass.242.3129
SMILESCCC12Cc3cc(O)ccc3C1=C(C)C(=O)CC2 |t:13|
Structure
n/a