Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 8
Ligand
BDBM50185909
Substrate
n/a
Meas. Tech.
ChEMBL_351818 (CHEMBL867801)
Ki
6±n/a nM
Citation
Ghosh, S; Elder, A; Guo, J; Mani, U; Patane, M; Carson, K; Ye, Q; Bennett, R; Chi, S; Jenkins, T; Guan, B; Kolbeck, R; Smith, S; Zhang, C; LaRosa, G; Jaffee, B; Yang, H; Eddy, P; Lu, C; Uttamsingh, V; Horlick, R; Harriman, G; Flynn, D Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8). J Med Chem 49:2669-72 (2006) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 8
Synonyms:
CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2
Type:
PROTEIN
Mol. Mass.:
40855.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_454278
Residue:
355
Sequence:
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
Inhibitor
Name:
BDBM50185909
Synonyms:
2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-2-methylpropanoic acid | CHEMBL205993
Type:
Small organic molecule
Emp. Form.:
C33H38ClN3O4
Mol. Mass.:
576.126
SMILES:
CC(C)(N1CCC(C1)(C(=O)NC1CCN(Cc2cccc(Oc3ccccc3Cl)c2)CC1)c1ccccc1)C(O)=O