Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50186296
Substrate
n/a
Meas. Tech.
ChEMBL_370710 (CHEMBL867233)
Ki
1.01±n/a nM
Citation
 Jesudason, CD; Beavers, LS; Cramer, JW; Dill, J; Finley, DR; Lindsley, CW; Stevens, FC; Gadski, RA; Oldham, SW; Pickard, RT; Siedem, CS; Sindelar, DK; Singh, A; Watson, BM; Hipskind, PA Synthesis and SAR of novel histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:3415-8 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50186296
Synonyms:
2-(cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinoline | CHEMBL212222
Type:
Small organic molecule
Emp. Form.:
C24H38N2O
Mol. Mass.:
370.5713
SMILES:
C(COc1ccc2CN(CC3CCCCC3)CCc2c1)CN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: