Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186836
Substrate
n/a
Meas. Tech.
ChEMBL_376573 (CHEMBL866622)
Ki
77±n/a nM
Citation
 Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 16:3674-8 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186836
Synonyms:
4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carboxylic acid amide | CHEMBL377270
Type:
Small organic molecule
Emp. Form.:
C31H28F4N4O
Mol. Mass.:
548.5738
SMILES:
NC(=O)c1cccc(c1)-c1ccc(cc1)C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)=C1CCN(CC2CC2)CC1 |(-4.22,4.69,;-5.56,3.92,;-6.89,4.69,;-5.56,2.38,;-6.89,1.61,;-6.89,.06,;-5.55,-.71,;-4.23,.06,;-4.22,1.61,;-2.89,-.7,;-2.9,-2.25,;-1.56,-3.02,;-.23,-2.25,;-.23,-.7,;-1.57,.07,;1.11,-3.02,;2.44,-2.24,;3.85,-2.87,;4.87,-1.72,;6.4,-1.73,;7.17,-.4,;6.4,.94,;7.17,2.27,;4.87,.93,;4.1,-.39,;2.6,-.71,;8.71,-.4,;10.25,-.39,;8.71,-1.94,;8.71,1.14,;1.11,-4.56,;-.23,-5.32,;-.23,-6.85,;1.1,-7.63,;1.1,-9.17,;-.24,-9.93,;-1.77,-9.93,;-1,-11.27,;2.44,-6.86,;2.44,-5.31,)|
Structure:
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