Target
Dimer of Tryptase beta-2
Ligand
BDBM50187177
Substrate
n/a
Meas. Tech.
ChEMBL_387229 (CHEMBL864198)
Ki
1.7±n/a nM
Citation
 Lee, CSLiu, WSprengeler, PASomoza, JRJanc, JWSperandio, DSpencer, JRGreen, MJMcGrath, ME Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles. Bioorg Med Chem Lett 16:4036-40 (2006) [PubMed]  Article 
Target
Name:
Dimer of Tryptase beta-2
Synonyms:
Tryptase beta-1/beta-2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 365130
Components:
This complex has 2 components.
Component 1
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Component 2
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50187177
Synonyms:
CHEMBL212774 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chlorophenyl)ethyl]carbamoyl}phenyl)methyl]-1,2,4-oxadiazol-3-yl}-1-oxohexan-2-yl]-3-fluorobenzamide
Type:
Small organic molecule
Emp. Form.:
C31H31ClFN5O4
Mol. Mass.:
592.06
SMILES:
NCCCC[C@H](NC(=O)c1cccc(F)c1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1
Structure:
Search PDB for entries with ligand similarity: