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Target
Tryptase
Ligand
BDBM50187800
Substrate
n/a
Meas. Tech.
ChEMBL_385584 (CHEMBL869805)
Ki
5.5±n/a nM
Citation
 Sperandio, D; Tai, VW; Lohman, J; Hirschbein, B; Mendonca, R; Lee, CS; Spencer, JR; Janc, J; Nguyen, M; Beltman, J; Sprengeler, P; Scheerens, H; Lin, T; Liu, L; Gadre, A; Kellogg, A; Green, MJ; McGrath, ME Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors. Bioorg Med Chem Lett 16:4085-9 (2006) [PubMed]  Article 
Target
Name:
Tryptase
Synonyms:
Mcp7 | Mcpt7 | TRYB1_RAT | Tpsab1 | Tpsb1 | Tryptase alpha/beta-1
Type:
PROTEIN
Mol. Mass.:
30399.92
Organism:
Rattus norvegicus
Description:
ChEMBL_385584
Residue:
273
Sequence:
MLKLLLLTLPLLSSLVHAAPSLAMPREGIVGGQEASGNKWPWQVSLRVNDTYWMHFCGGSLIHPQWVLTAAHCVGPNKADPNKLRVQLRKQYLYYHDHLLTVSQIISHPDFYIAQDGADIALLKLTNPVNITSNVHTVSLPPASETFPSGTLCWVTGWGNINNDVSLPPPFPLEEVQVPIVENRLCDLKYHKGLNTGDNVHIVRDDMLCAGNEGHDSCQGDSGGPLVCKVEDTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIYRYVPKYF
  
Inhibitor
Name:
BDBM50187800
Synonyms:
(S)-ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate | CHEMBL211561
Type:
Small organic molecule
Emp. Form.:
C26H32N4O5
Mol. Mass.:
480.5561
SMILES:
CCOC(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(OCCc3ccccc3)cc2)n1
Structure:
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