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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50188146
Substrate
n/a
Meas. Tech.
ChEMBL_384996 (CHEMBL869818)
Ki
231±n/a nM
Citation
 Huck, BR; Llamas, L; Robarge, MJ; Dent, TC; Song, J; Hodnick, WF; Crumrine, C; Stricker-Krongrad, A; Harrington, J; Brunden, KR; Bennani, YL The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist. Bioorg Med Chem Lett 16:4130-4 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50188146
Synonyms:
(3aS,8R,8aS)-6-chloro-5-ethoxy-8-methyl-1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrrole | CHEMBL211818
Type:
Small organic molecule
Emp. Form.:
C14H18ClNO
Mol. Mass.:
251.752
SMILES:
CCOc1cc2[C@H]3CNC[C@H]3[C@@H](C)c2cc1Cl
Structure:
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