Target
RAC-gamma serine/threonine-protein kinase
Ligand
BDBM50188922
Substrate
n/a
Meas. Tech.
ChEMBL_389599 (CHEMBL868042)
IC50
5200±n/a nM
Citation
 Lin, XMurray, JMRico, ACWang, MXChu, DTZhou, YDel Rosario, MKaufman, SMa, SFang, ECrawford, KJefferson, AB Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies. Bioorg Med Chem Lett 16:4163-8 (2006) [PubMed]  Article 
Target
Name:
RAC-gamma serine/threonine-protein kinase
Synonyms:
AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3
Type:
Enzyme
Mol. Mass.:
55769.36
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
479
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
  
Inhibitor
Name:
BDBM50188922
Synonyms:
4-(5-((2,4-dichlorophenethylamino)methyl)thiophen-2-yl)-N-methylpyrimidin-2-amine | CHEMBL214906
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2N4S
Mol. Mass.:
393.333
SMILES:
CNc1nccc(n1)-c1ccc(CNCCc2ccc(Cl)cc2Cl)s1
Structure:
Search PDB for entries with ligand similarity: