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Target
RAC-gamma serine/threonine-protein kinase
Ligand
BDBM50188944
Substrate
n/a
Meas. Tech.
ChEMBL_389599 (CHEMBL868042)
IC50
280±n/a nM
Citation
Lin, X; Murray, JM; Rico, AC; Wang, MX; Chu, DT; Zhou, Y; Del Rosario, M; Kaufman, S; Ma, S; Fang, E; Crawford, K; Jefferson, AB Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies. Bioorg Med Chem Lett 16:4163-8 (2006) [PubMed] Article
More Info.:
Target
Name:
RAC-gamma serine/threonine-protein kinase
Synonyms:
AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3
Type:
Enzyme
Mol. Mass.:
55769.36
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
479
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
Inhibitor
Name:
BDBM50188944
Synonyms:
CHEMBL211578 | N-((S)-3-(2,4-dichlorophenyl)-1-hydroxypropan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C19H18Cl2N4O2S
Mol. Mass.:
437.343
SMILES:
CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CO)Cc1ccc(Cl)cc1Cl