Reaction Details Report a problem with these data
Target
Amiloride-sensitive sodium channel subunit alpha
Ligand
BDBM50190468
Substrate
n/a
Meas. Tech.
ChEMBL_375179 (CHEMBL868533)
IC50
17±n/a nM
Citation
 Hirsh, AJ; Molino, BF; Zhang, J; Astakhova, N; Geiss, WB; Sargent, BJ; Swenson, BD; Usyatinsky, A; Wyle, MJ; Boucher, RC; Smith, RT; Zamurs, A; Johnson, MR Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem 49:4098-115 (2006) [PubMed]  Article 
Target
Name:
Amiloride-sensitive sodium channel subunit alpha
Synonyms:
Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel alpha-subunit | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A | SCNNA_HUMAN
Type:
PROTEIN
Mol. Mass.:
75711.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_375179
Residue:
669
Sequence:
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP
  
Inhibitor
Name:
BDBM50190468
Synonyms:
CHEMBL211600 | N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-{4-[3-(2-hydroxyethoxy)phenyl]-butyl}guanidine
Type:
Small organic molecule
Emp. Form.:
C18H24ClN7O3
Mol. Mass.:
421.881
SMILES:
NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCCO)c1 |w:14.15|
Structure:
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