Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50190981
Substrate
n/a
Meas. Tech.
ChEMBL_397859 (CHEMBL856320)
Ki
4200±n/a nM
Citation
 Chen, CW; Tran, JA; Jiang, W; Tucci, FC; Arellano, M; Wen, J; Fleck, BA; Marinkovic, D; White, NS; Pontillo, J; Saunders, J; Madan, A; Foster, AC; Chen, C Propionylpiperazines as human melanocortin-4 receptor ligands. Bioorg Med Chem Lett 16:4800-3 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50190981
Synonyms:
(S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)-2-(2,4-dichlorophenoxy)ethanone | CHEMBL380299
Type:
Small organic molecule
Emp. Form.:
C24H28Cl2F3N3O2
Mol. Mass.:
518.399
SMILES:
CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(Cl)cc1Cl)C(F)(F)F
Structure:
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