Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50193150
Substrate
n/a
Meas. Tech.
ChEMBL_422146 (CHEMBL863589)
Kd
230±n/a nM
Citation
 Choi, WJ; Shi, ZD; Worthy, KM; Bindu, L; Karki, RG; Nicklaus, MC; Fisher, RJ; Burke, TR Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles. Bioorg Med Chem Lett 16:5265-9 (2006) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50193150
Synonyms:
({4-[(5S,11S)-11-(carbamoylmethyl)-3,6,9,12-tetraoxo-1,4,7,10,13,18,19-heptaazaspiro[bicyclo[15.2.1]icosane-8,1'-cyclohexane]-17(20),18-dien-5-ylmethyl]phenyl}methyl)phosphonic acid | CHEMBL385458
Type:
Small organic molecule
Emp. Form.:
C28H39N8O8P
Mol. Mass.:
646.6318
SMILES:
NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(CP(O)(O)=O)cc2)NC(=O)Cn2cc(CCCNC1=O)nn2
Structure:
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