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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50193153
Substrate
n/a
Meas. Tech.
ChEMBL_422146 (CHEMBL863589)
Kd
1.1±n/a nM
Citation
 Choi, WJ; Shi, ZD; Worthy, KM; Bindu, L; Karki, RG; Nicklaus, MC; Fisher, RJ; Burke, TR Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles. Bioorg Med Chem Lett 16:5265-9 (2006) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50193153
Synonyms:
({4-[(2S)-2-[(1-{[(1S)-2-carbamoyl-1-({3-[1-({[(1S)-1-[(1-{[(1S)-2-carbamoyl-1-(pentylcarbamoyl)ethyl]carbamoyl}cyclohexyl)carbamoyl]-2-[4-(phosphonomethyl)phenyl]ethyl]carbamoyl}methyl)-1H-1,2,3-triazol-4-yl]propyl}carbamoyl)ethyl]carbamoyl}cyclohexyl)carbamoyl]-2-acetamidoethyl]phenyl}methyl)phosphonic acid | CHEMBL427641
Type:
Small organic molecule
Emp. Form.:
C56H83N13O16P2
Mol. Mass.:
1256.2832
SMILES:
CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)C1(CCCCC1)NC(=O)[C@H](Cc1ccc(CP(O)(O)=O)cc1)NC(=O)Cn1cc(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(CP(O)(O)=O)cc2)NC(C)=O)nn1
Structure:
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