Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50193307
Substrate
n/a
Meas. Tech.
ChEMBL_382040 (CHEMBL863653)
Ki
98.7±n/a nM
Citation
 Kolasa, T; Matulenko, MA; Hakeem, AA; Patel, MV; Mortell, K; Bhatia, P; Henry, R; Nakane, M; Hsieh, GC; Terranova, MA; Uchic, ME; Miller, LN; Chang, R; Donnelly-Roberts, DL; Namovic, MT; Hollingsworth, PR; Martino, B; El Kouhen, O; Marsh, KC; Wetter, JM; Moreland, RB; Brioni, JD; Stewart, AO 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. J Med Chem 49:5093-109 (2006) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50193307
Synonyms:
(E)-1-(3-chlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one O-methyloxime | CHEMBL212784
Type:
Small organic molecule
Emp. Form.:
C19H23ClN4O
Mol. Mass.:
358.865
SMILES:
CO\N=C(/CCN1CCN(CC1)c1ccccn1)c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: