Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50193375
Substrate
n/a
Meas. Tech.
ChEMBL_382039 (CHEMBL863651)
Ki
67.1±n/a nM
Citation
 Kolasa, T; Matulenko, MA; Hakeem, AA; Patel, MV; Mortell, K; Bhatia, P; Henry, R; Nakane, M; Hsieh, GC; Terranova, MA; Uchic, ME; Miller, LN; Chang, R; Donnelly-Roberts, DL; Namovic, MT; Hollingsworth, PR; Martino, B; El Kouhen, O; Marsh, KC; Wetter, JM; Moreland, RB; Brioni, JD; Stewart, AO 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. J Med Chem 49:5093-109 (2006) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50193375
Synonyms:
(E)-1-(4-chlorophenyl)-3-(2-methyl-4-pyridin-2-ylpiperazin-1-yl)propan-1-one O-methyloxime | CHEMBL212292
Type:
Small organic molecule
Emp. Form.:
C20H25ClN4O
Mol. Mass.:
372.892
SMILES:
CO\N=C(/CCN1CCN(CC1C)c1ccccn1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: