Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50193634
Substrate
n/a
Meas. Tech.
ChEMBL_421230 (CHEMBL856552)
IC50
4.4±n/a nM
Citation
 Jiang, J; Lin, P; Hoang, M; Chang, L; Tan, C; Feighner, S; Palyha, OC; Hreniuk, DL; Pan, J; Sailer, AW; Morin, NR; MacNeil, DJ; Howard, AD; Van der Ploeg, LH; Goulet, MT; DeVita, RJ 4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists. Bioorg Med Chem Lett 16:5275-9 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50193634
Synonyms:
CHEMBL214888 | N-(4-amino-2-propylquinolin-6-yl)-4-(4-chlorophenyl)cyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C25H28ClN3O
Mol. Mass.:
421.962
SMILES:
CCCc1cc(N)c2cc(NC(=O)C3CCC(CC3)c3ccc(Cl)cc3)ccc2n1 |(22.22,-15.01,;20.88,-14.24,;19.56,-15.01,;18.22,-14.25,;18.21,-12.7,;16.87,-11.94,;16.86,-10.4,;15.55,-12.72,;14.21,-11.95,;12.88,-12.73,;11.55,-11.96,;10.21,-12.73,;10.21,-14.27,;8.88,-11.96,;7.56,-12.73,;6.22,-11.97,;6.22,-10.42,;7.56,-9.65,;8.89,-10.41,;4.88,-9.65,;3.56,-10.42,;2.23,-9.67,;2.22,-8.12,;.89,-7.35,;3.55,-7.34,;4.89,-8.11,;12.88,-14.27,;14.21,-15.04,;15.55,-14.26,;16.89,-15.03,)|
Structure:
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