Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50193908
Substrate
n/a
Meas. Tech.
ChEMBL_424208 (CHEMBL908982)
IC50
128±n/a nM
Citation
 Noronha, GBarrett, KCao, JDneprovskaia, EFine, RGong, XGritzen, CHood, JKang, XKlebansky, BLi, GLiao, WLohse, DMak, CCMcPherson, APalanki, MSPathak, VPRenick, JSoll, RSplittgerber, UWrasidlo, WZeng, BZhao, NZhou, Y Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorg Med Chem Lett 16:5546-50 (2006) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50193908
Synonyms:
7-(2,6-dimethylphenyl)-5-methyl-N-(4-(piperazin-1-ylsulfonyl)phenyl)benzo[e][1,2,4]triazin-3-amine | CHEMBL218281 | US8481536, 426
Type:
Small organic molecule
Emp. Form.:
C26H28N6O2S
Mol. Mass.:
488.605
SMILES:
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(cc3)S(=O)(=O)N3CCNCC3)nnc2c1
Structure:
Search PDB for entries with ligand similarity: