Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50194274
Substrate
n/a
Meas. Tech.
ChEMBL_393088 (CHEMBL870440)
IC50
97±n/a nM
Citation
 Neumeyer, JL; Peng, X; Knapp, BI; Bidlack, JM; Lazarus, LH; Salvadori, S; Trapella, C; Balboni, G New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem 49:5640-3 (2006) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50194274
Synonyms:
(-)-H-Dmt-Tic-beta-Ala-O-3-hydroxy-N-cyclobutylmethylmorphinan | CHEMBL373984 | MCL-450
Type:
Small organic molecule
Emp. Form.:
C45H56N4O5
Mol. Mass.:
732.9499
SMILES:
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCCC(=O)Oc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3CC3CCC3)c2c1
Structure:
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