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Target
Adenosine receptor A3
Ligand
BDBM50199295
Substrate
n/a
Meas. Tech.
ChEMBL_412205 (CHEMBL910044)
Ki
>10000±n/a nM
Citation
 Vu, CB; Kiesman, WF; Conlon, PR; Lin, KC; Tam, M; Petter, RC; Smits, G; Lutterodt, F; Jin, X; Chen, L; Zhang, J Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists. J Med Chem 49:7132-9 (2006) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50199295
Synonyms:
(R)-3-(4-(8-isopropyl-5-oxo-4-propyl-4,5,7,8-tetrahydro-1H-imidazo[1,2-g]purin-2-yl)bicyclo[2.2.2]octan-1-yl)propanoic acid | CHEMBL216200
Type:
Small organic molecule
Emp. Form.:
C24H35N5O3
Mol. Mass.:
441.5664
SMILES:
CCCn1c2nc(nc2c2N[C@@H](Cn2c1=O)C(C)C)C12CCC(CCC(O)=O)(CC1)CC2
Structure:
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