Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM13014
Substrate
n/a
Meas. Tech.
ChEMBL_441055 (CHEMBL890212)
Ki
3.1±n/a nM
Citation
Grunewald, GL; Seim, MR; Regier, RC; Criscione, KR Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors. Bioorg Med Chem 15:1298-310 (2007) [PubMed] Article
More Info.:
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
Inhibitor
Name:
BDBM13014
Synonyms:
7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydrochloride | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | CHEMBL287837 | CHEMBL541797 | SKF 64139 | tetrahydroisoquinoline (THIQ) analogue
Type:
Small organic molecule
Emp. Form.:
C9H9Cl2N
Mol. Mass.:
202.08
SMILES:
Clc1ccc2CCNCc2c1Cl