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Target
Prostaglandin D2 receptor 2
Ligand
BDBM50200271
Substrate
n/a
Meas. Tech.
ChEMBL_408439 (CHEMBL908265)
IC50
3.2±n/a nM
Citation
 Ulven, T; Receveur, JM; Grimstrup, M; Rist, Ø; Frimurer, TM; Gerlach, LO; Mathiesen, JM; Kostenis, E; Uller, L; Högberg, T Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem 49:6638-41 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD294 antigen | Crth2 | G protein-coupled receptor 44 | Gpr44 | PD2R2_MOUSE | Ptgdr2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42975.89
Organism:
Mus musculus (mouse)
Description:
Human embryonic kidney (HEK) 293(EBNA) cells were transfected with mouse CRTH2.
Residue:
382
Sequence:
MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
  
Inhibitor
Name:
BDBM50200271
Synonyms:
4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid | CHEMBL217053
Type:
Small organic molecule
Emp. Form.:
C18H13BrN2O4
Mol. Mass.:
401.211
SMILES:
OC(=O)COc1ccc(Br)cc1C(=O)c1cnn(c1)-c1ccccc1
Structure:
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