Target
B2 bradykinin receptor
Ligand
BDBM50202419
Substrate
n/a
Meas. Tech.
ChEMBL_423710 (CHEMBL913022)
IC50
>10000±n/a nM
Citation
 Kuduk, SDDi Marco, CNChang, RKWood, MRSchirripa, KMKim, JJWai, JMDiPardo, RMMurphy, KLRansom, RWHarrell, CMReiss, DRHolahan, MACook, JHess, JFSain, NUrban, MOTang, CPrueksaritanont, TPettibone, DJBock, MG Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists. J Med Chem 50:272-82 (2007) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50202419
Synonyms:
3,3'-Difluoro-4'-({[1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid methyl ester | CHEMBL413775 | methyl 3,3'-difluoro-4'-{[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]methyl}-1,1'-biphenyl-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H17F5N2O4
Mol. Mass.:
456.3627
SMILES:
COC(=O)c1c(F)cccc1-c1ccc(CNC(=O)C2(CC2)NC(=O)C(F)(F)F)c(F)c1
Structure:
Search PDB for entries with ligand similarity: