Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50203533
Substrate
n/a
Meas. Tech.
ChEMBL_425538 (CHEMBL911375)
IC50
>5000±n/a nM
Citation
Yao, W; Zhuo, J; Burns, DM; Xu, M; Zhang, C; Li, YL; Qian, DQ; He, C; Weng, L; Shi, E; Lin, Q; Agrios, C; Burn, TC; Caulder, E; Covington, MB; Fridman, JS; Friedman, S; Katiyar, K; Hollis, G; Li, Y; Liu, C; Liu, X; Marando, CA; Newton, R; Pan, M; Scherle, P; Taylor, N; Vaddi, K; Wasserman, ZR; Wynn, R; Yeleswaram, S; Jalluri, R; Bower, M; Zhou, BB; Metcalf, B Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer. J Med Chem 50:603-6 (2007) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50203533
Synonyms:
(6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide | (6S,7S)-N-hydroxy-6-{[(3R)-3-phenylpyrrolidin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide | CHEMBL221698
Type:
Small organic molecule
Emp. Form.:
C19H25N3O3
Mol. Mass.:
343.4201
SMILES:
ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CC[C@@H](C1)c1ccccc1