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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50209808
Substrate
n/a
Meas. Tech.
ChEMBL_455313 (CHEMBL886089)
Ki
10±n/a nM
Citation
 Stocking, EM; Miller, JM; Barbier, AJ; Wilson, SJ; Boggs, JD; McAllister, HM; Wu, J; Lovenberg, TW; Carruthers, NI; Wolin, RL Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity. Bioorg Med Chem Lett 17:3130-5 (2007) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50209808
Synonyms:
CHEMBL248375 | N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)-3-(4-(trifluoromethyl)phenoxy)propan-1-amine
Type:
Small organic molecule
Emp. Form.:
C26H35F3N2O2
Mol. Mass.:
464.5635
SMILES:
CN(C)CCC(Oc1ccc(cc1)C(F)(F)F)c1ccc(OCCCN2CCCCC2)cc1 |w:5.4|
Structure:
Search PDB for entries with ligand similarity: