Target
C-C chemokine receptor type 3
Ligand
BDBM50209973
Substrate
n/a
Meas. Tech.
ChEMBL_458974 (CHEMBL925069)
IC50
1.5±n/a nM
Citation
 Pruitt, JRBatt, DGWacker, DABostrom, LLBooker, SKMcLaughlin, EHoughton, GCVarnes, JGChrist, DDCovington, MDas, AMDavies, PGraden, DKariv, IOrlovsky, YStowell, NCVaddi, KGWadman, EAWelch, PKYeleswaram, SSolomon, KANewton, RCDecicco, CPCarter, PHKo, SS CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett 17:2992-7 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50209973
Synonyms:
1-((3S,4S)-4-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)-1-(tetrahydro-2H-pyran-4-carbonyl)piperidin-3-yl)-3-(5-acetyl-4-methylthiazol-2-yl)urea | CHEMBL403743
Type:
Small organic molecule
Emp. Form.:
C31H42FN5O4S
Mol. Mass.:
599.76
SMILES:
CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C(=O)C2CCOCC2)nc1C
Structure:
Search PDB for entries with ligand similarity: