Reaction Details Report a problem with these data
Target
Glutamate receptor 1
Ligand
BDBM50166286
Substrate
n/a
Meas. Tech.
ChEMBL_435002 (CHEMBL920803)
Ki
0.15±n/a nM
Citation
 Vogensen, SB; Frydenvang, K; Greenwood, JR; Postorino, G; Nielsen, B; Pickering, DS; Ebert, B; Bølcho, U; Egebjerg, J; Gajhede, M; Kastrup, JS; Johansen, TN; Clausen, RP; Krogsgaard-Larsen, P A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J Med Chem 50:2408-14 (2007) [PubMed]  Article 
Target
Name:
Glutamate receptor 1
Synonyms:
AMPA-selective glutamate receptor 1 | GRIA1_RAT | GluA1 | GluR-1 | GluR-A | GluR-K1 | Glur1 | Glutamate receptor ionotropic, AMPA 1 | Gria1
Type:
Protein
Mol. Mass.:
101583.91
Organism:
Rattus norvegicus (Rat)
Description:
P19490
Residue:
907
Sequence:
MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL
  
Inhibitor
Name:
BDBM50166286
Synonyms:
(RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid | 2-Amino-3-[5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxy-isoxazol-4-yl]-propionic acid | 2-amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid | CHEMBL370941
Type:
Small organic molecule
Emp. Form.:
C9H12N6O4
Mol. Mass.:
268.2294
SMILES:
CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: