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Target
C-X-C chemokine receptor type 1
Ligand
BDBM50211451
Substrate
n/a
Meas. Tech.
ChEMBL_455596 (CHEMBL886376)
Ki
24±n/a nM
Citation
 Chao, J; Taveras, AG; Chao, J; Aki, C; Dwyer, M; Yu, Y; Purakkattle, B; Rindgen, D; Jakway, J; Hipkin, W; Fosetta, J; Fan, X; Lundell, D; Fine, J; Minnicozzi, M; Phillips, J; Merritt, JR C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists. Bioorg Med Chem Lett 17:3778-83 (2007) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50211451
Synonyms:
(R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(4-methylthiophen-2-yl)propylamino)-3,4-dioxocyclobut-1-enylamino)benzamide | CHEMBL393900
Type:
Small organic molecule
Emp. Form.:
C21H23N3O4S
Mol. Mass.:
413.49
SMILES:
CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C)cs1
Structure:
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