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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50213762
Substrate
n/a
Meas. Tech.
ChEMBL_447494 (CHEMBL896517)
IC50
250±n/a nM
Citation
 Wang, Y; Busch-Petersen, J; Wang, F; Ma, L; Fu, W; Kerns, JK; Jin, J; Palovich, MR; Shen, JK; Burman, M; Foley, JJ; Schmidt, DB; Hunsberger, GE; Sarau, HM; Widdowson, KL 3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists. Bioorg Med Chem Lett 17:3864-7 (2007) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50213762
Synonyms:
7-chloro-3-(2-methoxy-phenylamino)-1,1-dioxo-1,4-dihydro-1lambda6-benzo[1,2,4]thiadiazin-5-ol | CHEMBL233345
Type:
Small organic molecule
Emp. Form.:
C14H12ClN3O4S
Mol. Mass.:
353.781
SMILES:
COc1ccccc1NC1=Nc2c(O)cc(Cl)cc2S(=O)(=O)N1 |t:10|
Structure:
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