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Target
Matrilysin
Ligand
BDBM50216004
Substrate
n/a
Meas. Tech.
ChEMBL_456577 (CHEMBL922943)
Ki
635±n/a nM
Citation
 Gilmore, JL; King, BW; Asakawa, N; Harrison, K; Tebben, A; Sheppeck, JE; Liu, RQ; Covington, M; Duan, JJ Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett 17:4678-82 (2007) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50216004
Synonyms:
4-((2-methylquinolin-4-yl)methoxy)-N-(4-((5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-tetrahydro-2H-pyran-4-yl)benzamide | CHEMBL247140
Type:
Small organic molecule
Emp. Form.:
C26H27N5O3S
Mol. Mass.:
489.589
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)NC2(Cc3n[nH]c(=S)[nH]3)CCOCC2)c2ccccc2n1
Structure:
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