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Target
Adenosine receptor A3
Ligand
BDBM50218915
Substrate
n/a
Meas. Tech.
ChEMBL_445192 (CHEMBL894340)
Ki
9±n/a nM
Citation
 Colotta, V; Catarzi, D; Varano, F; Capelli, F; Lenzi, O; Filacchioni, G; Martini, C; Trincavelli, L; Ciampi, O; Pugliese, AM; Pedata, F; Schiesaro, A; Morizzo, E; Moro, S New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. J Med Chem 50:4061-74 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50218915
Synonyms:
CHEMBL397033 | N-(2-(4-methoxyphenyl)-2H-pyrazolo[3,4-c]quinolin-4-yl)-2,2-diphenylacetamide
Type:
Small organic molecule
Emp. Form.:
C31H24N4O2
Mol. Mass.:
484.5479
SMILES:
COc1ccc(cc1)-n1cc2c(n1)c(NC(=O)C(c1ccccc1)c1ccccc1)nc1ccccc21
Structure:
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