Reaction Details Report a problem with these data
Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM50220547
Substrate
n/a
Meas. Tech.
ChEMBL_457330 (CHEMBL941863)
Ki
400±n/a nM
Citation
 Tasdemir, D; Topaloglu, B; Perozzo, R; Brun, R; O'Neill, R; Carballeira, NM; Zhang, X; Tonge, PJ; Linden, A; Rüedi, P Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Bioorg Med Chem 15:6834-45 (2007) [PubMed]  Article 
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM50220547
Synonyms:
4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-amino-1H-imidazol-4-yl)-allyl]-amide | 4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-amino-3H-imidazol-4-yl)-allyl]-amide | CHEMBL397591 | oroidin | oroidin base
Type:
Small organic molecule
Emp. Form.:
C11H11Br2N5O
Mol. Mass.:
389.046
SMILES:
Nc1ncc(C=CCNC(=O)c2cc(Br)c(Br)[nH]2)[nH]1 |w:6.6|
Structure:
Search PDB for entries with ligand similarity: