Reaction Details Report a problem with these data
Target
Urotensin-2 receptor
Ligand
BDBM50224721
Substrate
n/a
Meas. Tech.
ChEMBL_450869 (CHEMBL899955)
Ki
77±n/a nM
Citation
Luci, DK; Ghosh, S; Smith, CE; Qi, J; Wang, Y; Haertlein, B; Parry, TJ; Li, J; Almond, HR; Minor, LK; Damiano, BP; Kinney, WA; Maryanoff, BE; Lawson, EC Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment. Bioorg Med Chem Lett 17:6489-92 (2007) [PubMed] Article
More Info.:
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42159.71
Organism:
Homo sapiens (Human)
Description:
Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:
389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
Inhibitor
Name:
BDBM50224721
Synonyms:
CHEMBL240916 | tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)ethyl)piperidin-4-yl)benzamido)ethyl)piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C34H45ClN4O5
Mol. Mass.:
625.198
SMILES:
CC(C)(C)OC(=O)N1CCC(CCNC(=O)c2cc(Cl)ccc2C2CCN(CCN3C(=O)COc4ccccc34)CC2)CC1