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Target
Beta-lactamase TEM
Ligand
BDBM50225388
Substrate
n/a
Meas. Tech.
ChEMBL_451362 (CHEMBL901565)
Ki
2500±n/a nM
Citation
 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. J Med Chem 50:5644-54 (2007) [PubMed]  Article 
Target
Name:
Beta-lactamase TEM
Synonyms:
BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla
Type:
Enzyme
Mol. Mass.:
31512.33
Organism:
Escherichia coli
Description:
P62593
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50225388
Synonyms:
CHEMBL236759 | thiophene-2-ylboronic acid
Type:
Small organic molecule
Emp. Form.:
C4H7BO2S
Mol. Mass.:
129.973
SMILES:
OB(O)C1=CCCS1 |t:3|
Structure:
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