Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50072985
Substrate
n/a
Meas. Tech.
ChEMBL_461584 (CHEMBL927607)
Ki
5000±n/a nM
Citation
 Grunewald, GL; Seim, MR; Bhat, SR; Wilson, ME; Criscione, KR Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. Bioorg Med Chem 16:542-59 (2008) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50072985
Synonyms:
1-(1,2,3,4-Tetrahydro-isoquinolin-7-yl)-ethanone | 1-(1,2,3,4-tetrahydroisoquinolin-7-yl)ethanone | CHEMBL26879
Type:
Small organic molecule
Emp. Form.:
C11H13NO
Mol. Mass.:
175.227
SMILES:
CC(=O)c1ccc2CCNCc2c1
Structure:
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