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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50241785
Substrate
n/a
Meas. Tech.
ChEMBL_526495 (CHEMBL975646)
IC50
6040±n/a nM
Citation
 Cheng, MC; Li, CY; Ko, HC; Ko, FN; Lin, YL; Wu, TS Antidepressant principles of the roots of Polygala tenuifolia. J Nat Prod 69:1305-9 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50241785
Synonyms:
3-O-benzoylpolygolitosyl-(2->1)-alpha-galactose | CHEMBL462805
Type:
Small organic molecule
Emp. Form.:
C19H28O10
Mol. Mass.:
416.4196
SMILES:
OC[C@@H]1OC[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@@H](OCc3ccccc3)[C@@H]2O)[C@H](O)[C@H]1O |r|
Structure:
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