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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50242791
Substrate
n/a
Meas. Tech.
ChEMBL_532146 (CHEMBL970333)
IC50
15400±n/a nM
Citation
 Jain, MR; Shetty, S; Chakrabarti, G; Pandya, V; Sharma, A; Parmar, B; Srivastava, S; Raviya, M; Soni, H; Patel, PR In vitro PAI-1 inhibitory activity of oxalamide derivatives. Eur J Med Chem 43:880-4 (2008) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50242791
Synonyms:
2-((3,5-bis(trifluoromethyl)benzyl)(4-(3-(trifluoromethoxy)phenylsulfonamido)phenyl)amino)-2-oxoacetic acid | CHEMBL503437
Type:
Small organic molecule
Emp. Form.:
C24H15F9N2O6S
Mol. Mass.:
630.436
SMILES:
OC(=O)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccc(NS(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1
Structure:
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