Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPlasminogen activator inhibitor-1
LigandBDBM50242788
Substrate/Competitorn/a
Meas. Tech.ChEMBL_532146
IC50>80000±n/a nM
Citation Jain, MRShetty, SChakrabarti, GPandya, VSharma, AParmar, BSrivastava, SRaviya, MSoni, HPatel, PR In vitro PAI-1 inhibitory activity of oxalamide derivatives. Eur J Med Chem43:880-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Plasminogen activator inhibitor-1
Name:Plasminogen activator inhibitor-1
Synonyms:Endothelial plasminogen activator inhibitor | PAI | PAI-1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator-1 (PAI-1)
Type:Enzyme
Mol. Mass.:45064.00
Organism:Homo sapiens (Human)
Description:P05121
Residue:402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50242788
NameBDBM50242788
Synonyms:2-((3,5-bis(trifluoromethyl)benzyl)(4-(4-methoxyphenylsulfonamido)phenyl)amino)-2-oxoacetic acid | CHEMBL459846
TypeSmall organic molecule
Emp. Form.C24H18F6N2O6S
Mol. Mass.576.465
SMILESCOc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)C(O)=O
Structure
n/a