Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50261195
Substrate
n/a
Meas. Tech.
ChEMBL_555590 (CHEMBL965637)
Ki
5.5±n/a nM
Citation
Chen, C; Tucci, FC; Jiang, W; Tran, JA; Fleck, BA; Hoare, SR; Wen, J; Chen, T; Johns, M; Markison, S; Foster, AC; Marinkovic, D; Chen, CW; Arellano, M; Harman, J; Saunders, J; Bozigian, H; Marks, D Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. Bioorg Med Chem 16:5606-18 (2008) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_RAT | Mc4r
Type:
PROTEIN
Mol. Mass.:
36892.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11005
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
Inhibitor
Name:
BDBM50261195
Synonyms:
1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine | CHEMBL497746
Type:
Small organic molecule
Emp. Form.:
C29H40ClFN4O2
Mol. Mass.:
531.105
SMILES:
CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1 |r|