Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50248929
Substrate
n/a
Meas. Tech.
ChEMBL_541388 (CHEMBL1023943)
Ki
3.9±n/a nM
Citation
 Zampieri, D; Grazia Mamolo, M; Laurini, E; Zanette, C; Florio, C; Collina, S; Rossi, D; Azzolina, O; Vio, L Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site. Eur J Med Chem 44:124-30 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50248929
Synonyms:
3-[[1-(4-Fluorobenzyl)piperidin-4-yl]methyl]benzo[d]oxazol-2(3H)-one | CHEMBL515571
Type:
Small organic molecule
Emp. Form.:
C20H21FN2O2
Mol. Mass.:
340.3913
SMILES:
Fc1ccc(CN2CCC(Cn3c4ccccc4oc3=O)CC2)cc1
Structure:
Search PDB for entries with ligand similarity: